Variations in Drug Response

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Using the knowledge you gained from the readings, evaluate how a typical drug, when orally administered, may be handled differently by these two patients:
Ms. Jones is a 30-year-old female personal trainer that is 5’ 4” tall weighing 110lbs. She regularly drinks socially and sometimes more than a bit when she meets with her bi-weekly book club. Mr. Smith is a 65-year-old software tester who is 6’ tall and weighs 235lbs. He drinks only occasionally. Assume no other significant medical history or issues with either patient. In your analysis, compare how the two patients will metabolize the drug considering weight, gender, distribution of body water and body fat, age, metabolic state, and alcohol use. Explain how these factors impact the pharmacokinetics of the drug (half-life, dosage, route of administration, and elimination of the drug). Evaluate the impact on the risk-benefits analysis of the use of this drug.
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Critical Review

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Select the topic for your Critical Review, which is due in Week Six, and briefly analyze its key features and pathophysiology. You may select from any of the following psychiatric disorders: schizophrenia (or schizotypal disorders), bipolar disorder, depression, any of the anxiety disorders, PTSD, chronic pain disorders, Alzheimer’s disease, Parkinson’s disease or other movement disorder, seizures, ADD/ADHD, autism, OCD, any personality disorder, brain trauma, stroke, encephalitis, meningitis, or migraines. Other topics may be chosen, with approval of your instructor.
Other topics may be considered but require prior approval by the instructor. However, addiction is not the emphasis of the course. Critical Reviews focusing on addiction, or drugs of addiction, will not be accepted. Your paper must focus on drug treatment and not on other modes of treatment. Papers that discuss psychotherapy, other than in passing, will not be given credit. Ask your instructor for clarification.
Explain your chosen psychiatric disorder in terms of neurotransmitter and receptor theories. Describe the symptomology of the disorder and its relationship with the neurotransmitters involved. Discuss the anatomic changes seen with the disorder. Explain the relationship between neurotransmitter and anatomic features and resultant symptoms. Summarize the interaction(s) between the behavioral, neuroanatomical, and neurotransmitter changes seen within the selected disorder.
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Pharmacological and Physiological Antagonism

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Prior to beginning work on this discussion, read the required chapters from the text and review the required articles for this week. Alcohol and caffeine have nearly opposite effects on behavior and the nervous system, yet these substances are not used to treat overdose or addiction to the other. Why not use caffeine to treat alcohol addiction? Analyze the issues of pharmacological and physiological antagonism. Explain the receptor systems involved and the central nervous system structures effects with regard to this question. Frame your analysis in terms of drug action first and other consequences second.
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Every Book on Your English Syllabus, Summed Up in a Single Sentence

Look, I don’t need to know why you’re here. I don’t need to know what misfortune has befallen you, what dark and winding road has led you to this low, low point in your life wherein you are Googling things like “[book title] summed up in a single sentence.” You hear me? If you have a test in twenty minutes that you didn’t study for, I don’t want to know about it. As far as I am concerned, you simply have a passion for books and a thirst for knowledge.

So, with that said, here they are—all the books you’ll ever have to read for English class (or at least some of them), summed up in a single sentence.

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Elaborate on the Topic for Your Critical Review …

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Elaborate on the Topic for Your Critical Review This assignment will be a continuation of the written assignment from Week One. Research a minimum of three peer-reviewed articles in addition to information from your text on the disorder you chose in Week One. Consider the key classes of drugs used to treat the disorder you chose in Week One and explain their action at the neurotransmitter system involved in the disease process. Analyze and describe the agonist-antagonist activity of the drugs and the receptor types and subtypes involved in the disorder. Elaborate on the receptor agonist-antagonist actions of the drugs and describe the most common side effects seen with these drugs. Evaluate the risk-benefits of drug use for this disorder.
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Simkins v. Moses H Cone

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In a well-organized, two to three-page essay (minimum 750 words) discuss the case of Simkins v. Moses H. Cone Memorial Hospital. Include how licensing laws may be used positively or negatively and incorporate Paul Tillich’s relational issues of love, power and justice.
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Case Study 1: Statistical Thinking in Health Care

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Ben Davis had just completed an intensive course in Statistical Thinking for Business Improvement, which was offered to all employees of a large health maintenance organization. There was no time to celebrate, however, because he was already under a lot of pressure. Ben works as a pharmacist’s assistant in the HMO’s pharmacy, and his manager, Juan de Pacotilla, was about to be fired. Juan’s dismissal appeared to be imminent due to numerous complaints, and even a few lawsuits over inaccurate prescriptions. Juan now was asking Ben for his assistance in trying to resolve the problem, preferably yesterday!
“Ben, I really need your help! If I can’t show some major improvement or at least a solid plan by next month, I’m history.” “I’ll be glad to help, Juan, but what can I do? I’m just a pharmacist’s assistant.” “I don’t care what your job title is; I think you’re just the person who can get this done. I realize I’ve been too far removed from day-to-day operations in the pharmacy, but you work there every day. You’re in a much better position to find out how to fix the problem. Just tell me what to do, and I’ll do it.” “But what about the statistical consultant you hired to analyze the data on inaccurate prescriptions?” “Ben, to be honest, I’m really disappointed with that guy. He has spent two weeks trying to come up with a new modeling approach to predict weekly inaccurate prescriptions. I tried to explain to him that I don’t want to predict the mistakes, I want to eliminate them! I don’t think I got through, however, because he said we need a month of additional data to verify the model, and then he can apply a new method he just read about in a journal to identify ‘change points in the time series,’ whatever that means. But get this, he will only identify the change points and send me a list; he says it’s my job to figure out what they mean and how to respond. I don’t know much about statistics — the only thing I remember from my course in college is that it was the worst course I ever took– but I’m becoming convinced that it actually doesn’t have much to offer in solving real problems. You’ve just gone through this statistical thinking course, though, so maybe you can see something I can’t. To me, statistical thinking sounds like an oxymoron. I realize it’s a long shot, but I was hoping you could use this as the project you need to officially complete the course.”
“I see your point, Juan. I felt the same way, too. This course was interesting, though, because it didn’t focus on crunching numbers. I have some ideas about how we can approach making improvements in prescription accuracy, and I think this would be a great project. We may not be able to solve it ourselves, however. As you know, there is a lot of finger-pointing going on; the pharmacists blame sloppy handwriting and incomplete instructions from doctors for the problem; doctors blame pharmacy assistants like me who actually do most of the computer entry of the prescriptions, claiming that we are incompetent; and the assistants tend to blame the pharmacists for assuming too much about our knowledge of medical terminology, brand names, known drug interactions, and so on.” “It sounds like there’s no hope, Ben!”
“I wouldn’t say that at all, Juan. It’s just that there may be no quick fix we can do by ourselves in the pharmacy. Let me explain how I’m thinking about this and how I would propose attacking the problem using what I just learned in the statistical thinking course.”
Source: G. C. Britz, D. W. Emerling, L. B. Hare, R. W. Hoerl, & J. E. Shade. “How to Teach Others to Apply Statistical Thinking.” Quality Progress (June 1997): 67–80.
Assuming the role of Ben Davis, write a three to four (3-4) page paper in which you apply the approach discussed in the textbook to this problem. You’ll have to make some assumptions about the processes used by the HMO pharmacy. Also, please use the Internet and/or Strayer LRC to research articles on common problems or errors that pharmacies face. Your paper should address the following points:
Develop a process map about the prescription filling process for HMO’s pharmacy, in which you specify the key problems that the HMO’s pharmacy might be experiencing. Next, use the supplier, input, process steps, output, and customer (SIPOC) model to analyze the HMO pharmacy’s business process. Analyze the process map and SIPOC model to identify possible main root causes of the problems. Next, categorize whether the main root causes of the problem are special causes or common causes. Provide a rationale for your response. Suggest the main tools that you would use and the data that you would collect in order to analyze the business process and correct the problem. Justify your response. Propose one (1) solution to the HMO pharmacy’s on-going problem(s) and propose one (1) strategy to measure the aforementioned solution. Provide a rationale for your response. Use at least two (2) quality references. Note: Wikipedia and other Websites do not qualify as academic resources. Your assignment must follow these formatting requirements:
Describe how organizations use statistical thinking to be more competitive. Apply the basic principles of statistical thinking to business processes. Apply the SIPOC model to identify OFIs in business processes. Use technology and information resources to research issues in business process improvement. Write clearly and concisely about business process improvement using proper writing mechanics.
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Week 4 mini case

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Please read the attached Mini case answer the following “questions for discussion.”
1-What makes a CEO’s job so complex? Use the mini-case to provide examples that help support your answer. 2- Is it good practice to rehire a former CEO who has retired? Please explain the potential advantages and disadvantages of doing so. 3- What should P&G do to replace Lafley when he retires for a second time? What actions should they take to prepare for the succession?
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MNA1161 – Assignment No. 14

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Write a short answer (1 -2 paragraphs) responding to each of the following prompts. While your responses will be you expressing your opinion, you can’t really be wrong, but you are expected to provide thoughtful, complete, candid responses.
A. We discussed the idea of feeling that you have a responsibility to the customer is probably a good thing, regardless of how far from actual customer contact. Do you employ that idea in your current position? If not, can you understand how that type of attitude is not only good for the company and customer, but for the worker as well?
B. Take a critical look at yourself. When you consider the way you interact with others in a professional setting, do you detect any habit, traits, characteristics, etc., that you think you could improve upon? Assuming you do have areas in which you could improve yourself, please discuss them and your opportunities briefly.
C. We also looked at the disconnect someone who deals with the public must develop to guard against taking rants directed at them as a company representative personally. Do you have that ability not let unreasonable personal attacks “get to you”, or do you think you’d take that kind of issue “home with you”?
D. Finally, how likely would you consider a career in customer service to be for you? If you have experience in that field (retail, for example) please elaborate on that; otherwise, just give it your best guess. Experienced or not, please provide some rationale for your inclinations.
 
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ELL Week 1 Discussion 1

Paper , Order, or Assignment Requirements
Understanding the Importance of Language Objectives [WLOs: 1, 2, 3, 4] [CLOs: 1, 2, 3, 4] Using the information below, in addition to what you have already read, and based on the context of working with children and adults, read and answer the following questions in a PowerPoint (PPT) or PPT with voice-over (for assistance, see Record a Slide Show With Narration and Slide Timings (Links to an external site.)Links to an external site.). You can also use a format such as Screencast-O-Matic (Links to an external site.)Links to an external site. to create your presentation. You can also use the voice recording feature in PPT. Respond to either the K-12 or adult learning questions, but not both. To structure your presentation, Your audience will be a group of colleagues or community members who are unfamiliar with these ideas. Be sure to explain in a way that shows that you understand and can explain the information. Your role will be an informed colleague or community member. The format will be a PowerPoint, PPT with voice-over, or Screencast-O-Matic (Links to an external site.)Links to an external site. to replicate a presentation. The purpose is to present a clear understanding of the importance of using language objectives when planning for ELLs. You are writing using an academic information style in your PPT (see The Informative Essay (Links to an external site.)Links to an external site. for assistance).
Children or Students in a K-12 Learning Context
Read Himmel’s Language Objectives: The Key to Effective Content Area Instruction for English Learners (Links to an external site.)Links to an external site. (n.d.). In your presentation or screencast: http://www.colorincolorado.org/article/language-objectives-key-effective-content-area-instruction-english-learners
● Explain the importance of language objectives for teaching ELLs.
● Determine how the factors that impede language acquisition might alter language objectives.
● Support why teachers need to understand language goals before creating lesson plans.
● Evaluate how the language objectives in each domain might differ.
The Understanding the Importance of Language Objectives presentation
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